| Schütz Consulting | Baden-Württemberg |
| Schwaben Systems GmbH | |
| Schwäbischer Verlag GmbH & Co. KG | |
| Schwalm M Robotic GmbH | |
| Schwanthaler Computer GmbH & Co. KG | Bavaria |
| Schwarz Computer Systeme GmbH | Bavaria |
| Schwarz Corporate Solutions KG | Baden-Württemberg |
| Schwarz IT KG | Baden-Württemberg |
| Schwarz System Consulting GmbH | Bavaria |
| Schwebke Softwareentwicklung | Baden-Württemberg |
| Schweizer Electronic AG | |
| Schwemberger Elektronik GmbH | Bavaria |
| Schwer + Kopka GmbH | Baden-Württemberg |
| Schwinkendorf Service GmbH | Baden-Württemberg |
| Sci Worx GmbH | Lower Saxony |
| ScienceUp | Bavaria |
| Scientec Internet Applications and Media GmbH | Hamburg |
| SciFlow GmbH | |
| SCIO Automation GmbH | |
| SCIO Technology GmbH | Bavaria |
| Sciomics GmbH | |
| Sciopta Systems GmbH | Baden-Württemberg |
| scireum GmbH | Baden-Württemberg |
| SciRhom GmbH | |
| Scitaris GmbH & Co. KG | |
| SCM Solutions GmbH | North Rhine-Westphalia |
| SCN GmbH | North Rhine-Westphalia |
| SCNE UG (haftungsbeschränkt) | |
| Scobees GmbH | |
| Scompler Technologies GmbH | |
| SCOPAR GmbH | Bavaria |
| Scope International AG | |
| Scopevisio AG | North Rhine-Westphalia |
| Scoutbee GmbH | |
| Screen Charm | |
| Screen Solutions GmbH & Co. KG | Baden-Württemberg |
| Screen-Tech | Hamburg |
| screenbow GmbH & Co. KG | Hesse |
| Screendesignshop.de | North Rhine-Westphalia |
| Screengallery | Baden-Württemberg |
| Script Soft | Hesse |
| scRNA-tools | |
| Scrutinizer GmbH | |
| SCSI Schulungscenter GmbH | Baden-Württemberg |
| Sct Schiele GmbH | Baden-Württemberg |
| SD Software GmbH | North Rhine-Westphalia |
| SD Software nach Maß GmbH | Saarland |
| SD Solutions e.K. | Bavaria |
| SD-M GmbH | |
| SDC Ventures GmbH | |