| Sascha Willwacher Software GmbH | Rhineland-Palatinate |
| SASKIA Informations-Systeme GmbH | Saxony |
| Sasse Elektronik GmbH | Bavaria |
| sasserath+ consultants GmbH | |
| Sastrify GmbH | |
| Satboy, Stefan Erdmann | North Rhine-Westphalia |
| Saticon GmbH | North Rhine-Westphalia |
| SatKing GmbH | North Rhine-Westphalia |
| SatService | Baden-Württemberg |
| Sattler EDV-Services GmbH | Hesse |
| Satware AG | Rhineland-Palatinate |
| Satzmedia GmbH | Hamburg |
| Sauer Design | Hesse |
| Sauer Engineering GmbH | North Rhine-Westphalia |
| SAUER Organisation+Software GmbH | Bavaria |
| Saupe Communication GmbH | |
| Sauter Cumulus GmbH | Baden-Württemberg |
| Savage Game Studios | |
| SaveIP GmbH | Hesse |
| Savignano Software Solutions | Baden-Württemberg |
| Savit GmbH | Schleswig-Holstein |
| Savvynet GmbH & Co. KG | |
| SaxoCell | |
| Saxonia Network Systems GmbH | |
| SBC GmbH | Baden-Württemberg |
| SBC Systems GmbH | Hesse |
| SBIT AG | |
| SBK Studio UG (haftungsbeschränkt) | Hamburg |
| SBS Datentechnik | Bavaria |
| SbS EDV Beratung Rainer Gehrig | Baden-Württemberg |
| SBS-Softwaresysteme GmbH | Lower Saxony |
| SBSK GmbH & Co. KG | Saxony-Anhalt |
| SC Electronic Service GmbH | North Rhine-Westphalia |
| SC Soft-Concept GmbH | Hamburg |
| SC-Networks GmbH | Bavaria |
| Scailex GmbH | |
| Scalable Capital GmbH | Bavaria |
| ScaleCommerce GmbH | |
| ScaleHub GmbH | |
| ScaleNC GmbH | |
| ScaleUp Technologies GmbH & Co. KG | |
| Scaling Agriculture Innovations through Start-ups | |
| Scanbot SDK GmbH | |
| ScanDig GmbH | Bavaria |
| Scandinavian Business Hub | |
| Scandio GmbH | Bavaria |
| SCANLAB GmbH | |
| Scanplus GmbH | Baden-Württemberg |
| Scantinel Photonics | |
| Scanware Electronic GmbH | Hesse |