| Rehasoft, S.L. | Barcelona |
| Rekom Biotech, S.L. | |
| Relevant Traffic | Madrid |
| Remuner, S.L. | |
| Renpo Digital Consulting | |
| Rentals United | Barcelona |
| Rentasoft S.A. | Sevilla |
| Rentservice Informática, S.L.U. | Madrid |
| Reparanet | Madrid |
| Replicalia, S.L. | Barcelona |
| República Web | Valencia |
| Residència d'Investigadors | |
| Retinset, S.L. | Barcelona |
| Reveal Genomics, S.L. | Barcelona |
| Rever | |
| Revista Byte TI | Madrid |
| Revista Transformación Digital | Madrid |
| Revolution Software, S.L. | Alicante |
| RGB Informàtica i Consulting, S.L. | Lleida |
| RIB Software SE | Madrid |
| Ribera Salud, S.A.U. | Valencia |
| Ric Energy | Madrid |
| Ricard Menor | |
| Ricardo García Vega | Asturias |
| Ricopia Technologies, S.A. | Madrid |
| Riello Enerdata, S.L.U. | Madrid |
| Rifé Electrònica, S.A. | Barcelona |
| Rigthdecisions Asesores Informáticos, S.L. | |
| Rio Ancho Multimedia, S.L. | Barcelona |
| Risc Informàtica | Tarragona |
| Rload | |
| Road To Data | Madrid |
| Rob Surgical | Barcelona |
| Roberto Romero | |
| ROBIT Sistemas Informaticos y Comunicaciones, S.L. | Madrid |
| Robot, S.A. | Balearic Islands |
| Robota | Madrid |
| Robotnik Automation, S.L. | Valencia |
| Robytec | Madrid |
| Rocket Studio | Madrid |
| ROI UP Group | |
| Rokubun | Barcelona |
| Rokubun, S.L. | Barcelona |
| Roline System | Barcelona |
| Romo Telecomunicaciones, S.L. | Biscay |
| Rompal | Barcelona |
| Roomleader | Barcelona |
| RPA Labs | |
| RS Cloud Soluciones Tecnológicas, S.L. | Madrid |
| RSB Agency | Barcelona |