| Orca | Valencia |
| Ordatic | Valencia |
| Organic Boosting | Valencia |
| Organización Nacional de Trasplantes | |
| Origami Soluciones | Pontevedra |
| Orisha Commerce | |
| Oroi Wellbeing, S.L. | Gipuzkoa |
| Orquest | Madrid |
| Oryzon Genomics, S.A. | Barcelona |
| Osés RFID, S.L. | Navarre |
| Outvise | Barcelona |
| Over The Top Games | Barcelona |
| Overalia | Gipuzkoa |
| Oversight | Santa Cruz de Tenerife |
| OWO | Málaga |
| OXOLIFE | |
| Ozono Multimedia, S.L.L. | A Coruña |
| P4Q | Biscay |
| Paack | Barcelona |
| Pacific Computers - Herrador Informática, S.L. | Madrid |
| PAL Robotics, S.L. | Barcelona |
| Palo BioFarma | Barcelona |
| Palo Seco Strategy | |
| Pampua | Alicante |
| Panda Security | Biscay |
| Pandorahub | Barcelona |
| Panel Systemas Informáticos, S.L. | |
| Pangaea Oncology | Barcelona |
| Pangea Aerospace | Barcelona |
| ParatuPc.es | Ciudad Real |
| Parc Cientific de Barcelona | Barcelona |
| Parc Científic de la Universitat de València | Valencia |
| Parc Científic i Tecnològic de Girona | Girona |
| Pariver, S.A. | Zaragoza |
| Parque Cientifico y Tecnologico Cartuja, S.A. | Sevilla |
| Parque Tecnológico de Andalucía | Málaga |
| Parsec Media, S.L. | |
| Parsec SYS, S.L. | Cantabria |
| Payflow Digital Inc Sucursal en España | Barcelona |
| Paymefy | Barcelona |
| PayRetailers | Barcelona |
| PayThunder | Barcelona |
| PBN Hosting, S.L. | Alicante |
| PC a medida | Pontevedra |
| PC Componentes y Multimedia, S.L.U. | Murcia |
| PC Factory Computer, S.L.U. | Madrid |
| PC Imagine, S.C.P. | Barcelona |
| PC Rednet, S.L. | Madrid |
| PCTECH Assistance | Madrid |
| Pctech Informática | Málaga |