| Densify | Ontario |
| Densitas, Inc. | |
| Dentem | Ontario |
| Denti.AI Technology, Inc. | |
| Dentrino AI | |
| Dépan Info | Quebec |
| Depaninfo | Quebec |
| Département TI | Quebec |
| Departure Lounge, Inc. | |
| Depatment of Computer Science Innovation Lab | Ontario |
| Dependable HomeTech | Ontario |
| Dependbuild | |
| Depix Technologies, Inc. | |
| Depp Sky | |
| Deprolabs | |
| Déraison | Quebec |
| Derivative | Ontario |
| Derivative Design | British Columbia |
| Derooted | Ontario |
| DERYtelecom | Quebec |
| Descent Exposure | Ontario |
| Descore, Inc. | Ontario |
| Descormiers et associés, Inc. | Quebec |
| Design 1st | Ontario |
| Design Boutique | Quebec |
| Design Boutique Daniel Brien, Inc. | |
| Design Centered | |
| Design Interpretive | Ontario |
| Design Labz | |
| Design Match | |
| Design Menu | British Columbia |
| Design of Develop | |
| Design Office Zen | Ontario |
| Design Quarry Print & Digital Solutions Ltd | Alberta |
| Design Shopp | Quebec |
| Design TACTICS | Ontario |
| Design Twist | Ontario |
| Design Workshop Technologies | Quebec |
| Design2Web IT, Inc. | British Columbia |
| Design4u.ca | Ontario |
| DesignDirective, Inc. | Ontario |
| Designer Web Solutions | British Columbia |
| DesignerWhere.com | British Columbia |
| Designful | |
| Designfusion | Ontario |
| Designignite | Ontario |
| DesignIt! | British Columbia |
| DesignMédia | Quebec |
| Designo Graphy | |
| Designs Cottage | |