| CretMark Digital Solutions | |
| Crew Marketing Partners | |
| Crewsoft, Inc. | Alberta |
| Crhouse Technology, Inc. | Ontario |
| CRI agence | |
| Crimson Design | British Columbia |
| CrimsonLogic (North America), Inc. | Ontario |
| CriSys Ltd | Ontario |
| Critical Control Energy Services Corporation | Alberta |
| Critical Elements Lithium Corporation | |
| Critical Industrial Technologies | |
| Critical Mass | Alberta |
| Critical System Labs, Inc. | British Columbia |
| CRITM | |
| CRM Dynamics | Ontario |
| CRM Québec | |
| CRM Systems | Manitoba |
| CRMUnleashed | British Columbia |
| CRO Software Solutions | |
| Crocus Plains | Alberta |
| Croesus | Quebec |
| Cromwell Management Québec, Inc. | |
| Cronomagic Canada, Inc. | Quebec |
| CrookedBush | Ontario |
| CrookedStick UpdatePanel | Ontario |
| CropMind | |
| Cross Roads Solutions | |
| Cross-Border Impact Ventures | |
| Crossbow Interactive | Nova Scotia |
| Crossbow Interactive Web Design | |
| Crosscheck Networks Canada | Ontario |
| CrossLake Fibre | |
| CrossLeaf Web Engineering | |
| Crosslight Software | British Columbia |
| Crosswinds Internet Communications, Inc. | Ontario |
| Crow Computing Ltd | British Columbia |
| CrowdChat, Inc. | Quebec |
| CrowdRiff | Ontario |
| Crown Capital Partners, Inc. | |
| Crown Computers, Inc. | Saskatchewan |
| Crown Design Lane | |
| Crown Investments Corporation of Saskatchewan | |
| Crozdesk | |
| CRRS | Newfoundland and Labrador |
| Crux OCM | Alberta |
| CruxOCM | |
| CRW Systems Manitoba, Inc. | |
| CryoStasis, Inc. | |
| CrypKey, Inc. | Alberta |
| Crypto4A Technologies | |