| Corridor Interactive, Inc. | Alberta |
| Corsa Technology, Inc. | |
| Corsac Technologies Corporation | Ontario |
| CORSphere Software, Inc. | |
| Cortex Business Solutions, Inc. | Alberta |
| Cortex Design, Inc. | Ontario |
| Corus Entertainment, Inc. | |
| CorVista Health, Inc. | |
| Cosat Informatique | Quebec |
| Cosbit, Inc. | Alberta |
| Cosciens Biopharma | |
| Cosior, Inc. | Quebec |
| Cosm Medical | |
| Cosmic Development | |
| Cosmin Smeu | Ontario |
| Cosmo Creations | New Brunswick |
| Cosotech Informatique | Quebec |
| Costa Leclerc Design | Ontario |
| Costar Computer Systems | Alberta |
| Costarter | |
| Côté Connect | |
| COTE Logistique | Quebec |
| Cotec Advanced Systems, Inc. | Ontario |
| CottageDATA.com | Nova Scotia |
| Couch & Associates, Inc. | Ontario |
| Coulter Software, Inc. | Ontario |
| Council of Canadian Innovators | Ontario |
| Council of the Great Lakes Region | |
| Countable Web Productions | British Columbia |
| CounterPath | British Columbia |
| Country Graphics and Printing Ltd | Manitoba |
| Country Nerd | Ontario |
| Courant Plus | Quebec |
| Cournoyer communication marketing | |
| Course Compare | |
| Course Studio, Inc. | |
| CourseConnect | |
| CourseGuru | |
| CoursePeer | |
| Courtech - Recrutement et services conseils | Quebec |
| Cova | |
| Covalon Technologies Ltd | Ontario |
| Covenant Health | |
| Coventry Connections | Ontario |
| Coveo Solutions, Inc. | Quebec |
| Covspect | |
| Cowley and Associates | Ontario |
| Coworking Alphard | |
| Coworking Canada | Ontario |
| Coworking Du Plateau | |