| Memtec | Gauteng |
| Metacom | Western Cape |
| MetaImago | |
| Metcore IT Consult | Limpopo |
| Methys | |
| METIS Marketing Solutions | Western Cape |
| Metrofile (Pty) Ltd | Free State |
| MFS Africa Ltd | |
| Mfundisi Consulting | Western Cape |
| MG Creations | KwaZulu-Natal |
| MicroAce CC | KwaZulu-Natal |
| Micrographics | Gauteng |
| Micros South Africa | Gauteng |
| Microserve Design Studio | Western Cape |
| MIcrosoft South Africa | Gauteng |
| Microsystems On Silicon (Pty) Ltd | Gauteng |
| MicroVision Software | KwaZulu-Natal |
| MiDAS Management Systems CC | Gauteng |
| Millpark | |
| Mindjoy Learning, Inc. | |
| Minesoft | Gauteng |
| MiniMi Small Business Solutions | |
| Mintcube | Western Cape |
| Mintek | |
| Miosa Twenty-Four Pty Ltd | Gauteng |
| MIP Holdings (Pty) Ltd | |
| Miro Distribution | Gauteng |
| Mitsol (Pty) Ltd | KwaZulu-Natal |
| MIX Telematics | Western Cape |
| Mkhaya | |
| mLab | Gauteng |
| MMC | Western Cape |
| MN Software | Western Cape |
| MO Agency | |
| Moamak Trading | |
| Mobicred (Pty) Ltd | |
| Mobile Intergrated Technologies | Gauteng |
| MobileWarehouse | Gauteng |
| Model Maker Systems | Gauteng |
| Modena | Gauteng |
| Modern Day Strategy | |
| Monstermedia | KwaZulu-Natal |
| Mont6 Technologies (Pty) Ltd | Gauteng |
| Mont6 Technologies (Pty) Ltd | |
| MoonShot Labs | |
| Mopani South East TVET College | |
| More Clicks | Western Cape |
| Motribe Mobile Networks | |
| Mozami.net | KwaZulu-Natal |
| MPCS | Western Cape |