| Simplicity Concept Nigeria | |
| Simtech Creative | |
| Siniotech | |
| Site7 Designs Company | Lagos |
| Site7SMS | Lagos |
| Skill Seeds Ltd | |
| Skillmatic Ace Ltd | |
| Skyline University Nigeria | |
| Slatecube Talent Accelerator Ltd | Lagos |
| Slink Digital Technologies | |
| SlyFig Tech | |
| Smart Spaces | |
| Smart X Business Hub | Lagos |
| Smartware Innovation | |
| Smile Identity, Inc. | Lagos |
| Socialander Digital Agency | |
| Soft Solutions Ltd | Lagos |
| Softcity Group | |
| Softcodes International Ltd | |
| Softhood Technologies | |
| Sokoto State University, Sokoto | |
| Solarex IT World | |
| Soscify | |
| Southwestern University, Nigeria | |
| SpacePointe Ltd | Lagos |
| Spearhead Solutions | |
| Special Man Global Solution Ltd | Lagos |
| SPENN | Federal Capital Territory |
| Spiritan University | |
| Sprinble | Lagos |
| Sprinters Technologies Ltd | |
| SQT Web Solutions.com | |
| Stanbic IBTC | Lagos |
| Start Innovation Hub | |
| StartPreneurs | |
| Startup Lagos | Lagos |
| Startup Nigeria | Lagos |
| StartupList Africa | Federal Capital Territory |
| State College of Basic & Remedial Studies, Sokoto | |
| Stay Media | |
| Stears | Lagos |
| Stile Tech Advert | |
| Stoic-B Technologies Ltd | |
| StudySearch | Lagos |
| Suhailsen Technologies | |
| Sule Lamido University | |
| Summit Unversity | |
| Summitech | |
| SumoTrust | Federal Capital Territory |
| Super Stars Promotions Ltd | Lagos |