| DealDrive | |
| Defyca Holdings S.à r.l. | |
| Delfin Studio | |
| DellMont | Luxembourg |
| Dennemeyer S.A. | Luxembourg |
| Devseis Consultancy S.à.r.l.s. | |
| DevStrat S.A. | |
| Diagenics Group SE | |
| Diffusion Internationale Luxembourg | Luxembourg |
| Digital Health Network | |
| Digital Innovation Hub | |
| Digital Learning Hub | Esch-sur-Alzette |
| Digital Luxembourg | Luxembourg |
| Digitec S.à.r.l. | Redange |
| Distribio | |
| Distribution de Matériel Électrique | Esch-sur-Alzette |
| DNS Luxembourg | Esch-sur-Alzette |
| DNX Network S.à r.l. | |
| Doctena S.A. | Luxembourg |
| Done S.A.R.L. | |
| Dorr & Boël | Luxembourg |
| Dotcom Luxembourg | Luxembourg |
| e-connect | Luxembourg |
| E-hosting.lu | Capellen |
| e-Technologies S.A. | Luxembourg |
| E-volution S.A. | Luxembourg |
| e-Xstream | |
| E3 Consult | |
| EBRAND | Esch-sur-Alzette |
| EBRC S.A. | Luxembourg |
| EducDesign s.a. | Esch-sur-Alzette |
| electro-HAUSER | Luxembourg |
| Eliacin | |
| Eltrona Interdiffusion S.A. | Luxembourg |
| Emailtree.ai | |
| EMMA technologies S.a.r.l. | |
| Emma Technologies S.a.r.l.-S | |
| EmTroniX | Esch-sur-Alzette |
| Enamply | |
| Encryption Europe | |
| Endotelix Diagnostics S.à r.l. | |
| Energie et Environnement S.A. | |
| Enovos Luxembourg S.A. | |
| Espresso Web Studio | Luxembourg |
| Estating Property Vault S.A. | |
| Etix Everywhere | Luxembourg |
| Eurobase GmbH | Grevenmacher |
| EuroCloud | Luxembourg |
| EuroDNS S.A. | Esch-sur-Alzette |
| Europe Online | Luxembourg |