| Quanta | |
| Quantoom Biosciences | |
| Quidditas Therapeutics | |
| QWAY.energy | |
| R.A.V.E.N. Zaventem | |
| Rack66 Colocation | East Flanders |
| Radiomics | |
| Radix | |
| Rafusoft | |
| Railnova S.A. | |
| Raincode | Brussels-Capital |
| Raincode Labs | Brussels-Capital |
| Ramasoft | |
| RealDomen | Flemish Brabant |
| Reality Matters | Antwerp |
| Reality Sys S.A. | Liège |
| Recupel | Brussels-Capital |
| Redcorp | Brussels-Capital |
| Référenceur.be S.P.R.L. | Liège |
| Register SA/NV | Brussels-Capital |
| Register.be | Brussels-Capital |
| REIN4CED | |
| Rejuvenate Biomed N.V. | |
| Rekall Design | Antwerp |
| Remmicom | Antwerp |
| reMYND | |
| Replay | |
| Resillion | |
| Restomax | Brussels-Capital |
| Revatis S.A. | |
| Rewind Therapeutics | |
| RheaVita | |
| Riaktr | |
| Rise Financials SRL | |
| Riseweb | |
| Roam B.V.B.A. | Limburg |
| Robarov | Antwerp |
| Robbell | East Flanders |
| Robert Bosch N.V. | Brussels-Capital |
| Robotics & Design BVBA | Antwerp |
| Rock.estate | Brussels-Capital |
| Roland DG Benelux N.V. | Antwerp |
| Rombit | |
| Roots N.V. | Antwerp |
| Royal Academies for Sciences and Arts of Belgium | Brussels-Capital |
| Royal Belgian Institute for Space Aeronomy | |
| RTLOC | |
| Ruben Vermeersch | Flemish Brabant |
| Rydoo | Antwerp |
| S-Biomedic N.V. | |