| Name | Region |
|---|---|
| Sait | Kiev |
| Sales'Up | |
| Salesforce24 | Lviv |
| Salon-Manager | Kiev |
| Samsung Ukraine | Kiev |
| SAPHIRA Agency | |
| Sapient Pro | |
| Sargas | |
| Satellite ISP | Dnipropetrovsk |
| Scalabium Software | Kiev |
| Scalefocus AD | |
| School Today | |
| Science and Technology Center in Ukraine | Kiev |
| SciForce | |
| Screen Interactive | Kharkiv |
| SD Solutions | Kiev |
| SDA Company | Kharkiv |
| SDD Technology | |
| SecretLab | |
| Seedium | |
| Selena | Kiev |
| SelpMe | |
| Sense Production | |
| SenSeo | |
| Sensters | |
| Seo Audit Conus | Kiev |
| Seo-evolution | |
| SEO-Studio | |
| Seo.Ua | |
| SEObanda Ltd | |
| SEOHelp.ua | Kiev |
| SEOinar | |
| Seok.ua | |
| SeoMaker.Pro | |
| Seomix | Kiev |
| SeoProfy | |
| SEOTM | Kiev |
| SeoTOP | Kharkiv |
| Serpstat | |
| Service.so | |
| SET University | |
| Seven Moutains | |
| Seven Studio | |
| SevenPro | |
| Seventeam | |
| Several Clouds | |
| SGAMES | Kiev |
| Shedix.com | Kiev |
| SheepFish | |
| ShiftCMS | Lviv |