| Interworks GmbH | Aargau |
| Inthera Bioscience | |
| Invasight | |
| Inventec Informatik AG | Zurich |
| Inventx | Grisons |
| InvestGlass S.A. | |
| Investivity | |
| InVirtuoLabs | |
| Invision AG | |
| Inware AG | Zurich |
| Inyova AG | |
| iomedia Communication S.A. | Vaud |
| iOnctura | |
| Ionesoft GmbH | Bern |
| IoT Lab | |
| IP Exchange | Nidwalden |
| IP worldcom S.A. | Vaud |
| IPG AG | Zurich |
| IPOR | |
| Iprotus | Zug |
| Iprova S.A. | |
| IPS.ch | Zug |
| ipSpace.net AG | |
| iQone Healthcare Switzerland | |
| iRewind AG | |
| Irmos Technologies GmbH | |
| Isatel Electronic AG | Zug |
| iSD - intelligent Systems Design - Elektronikentwicklungen | Bern |
| iShop.ch | Bern |
| isi-comp Computerdienstleistung | Zurich |
| Isomet AG | Zurich |
| Isonet | Zurich |
| Isospec Analytics | |
| iSource AG | Zurich |
| ISP Solutions S.A. | Vaud |
| ispace.ch GmbH | Zurich |
| IST System-Vertrieb GmbH | Aargau |
| Istituto Dalle Molle di Studi sull'Intelligenza Artificiale | Ticino |
| IT Armour | |
| IT Factory AG | Thurgau |
| IT Recruitment GmbH | Zurich |
| IT-Sec.ch | Aargau |
| ITech Consult AG | Zug |
| ITM Development S.à.r.l. | |
| Itopie Informatique | |
| iWay AG | Zurich |
| iWedia S.A. | |
| Ixact AG | Solothurn |
| j-media GmbH | St. Gallen |
| Jad System S.A. | Geneva |