| SoftWorks S.R.L. | Bihor |
| SolCreation | Cluj |
| Soleadify | Bucharest |
| Soliton Computers | Bucharest |
| Solutii Web | Bihor |
| Solvo S.R.L. | |
| Spaceapps | |
| SpaceHub Incubator | |
| Sparking Capital | |
| Spatiul Ro | Iași |
| Spatiuweb | Iași |
| Spearhead Systems | |
| SpeedHost.ro | Timiș |
| Spherik Accelerator | Cluj |
| Sphinx IT | Timiș |
| Sprint Owl S.R.L. | |
| Spyhce | Cluj |
| SRD Media IT Consulting S.R.L. | |
| SRK S.R.L. | Cluj |
| SRV.RO | Bucharest |
| Standby Team | |
| Star Taxi | Bucharest |
| StarCluster | |
| start-up.ro | |
| Startarium | |
| StarTech Team | |
| Started Agency | |
| Startup Romania | Bucharest |
| Startup Spinner Markeathon | |
| StartupCafe.ro | |
| Startweb | |
| StasOnline | Timiș |
| Stater | |
| Steepsoft AI S.R.L. | |
| Stefanini Infinit | |
| StegaCreative | |
| Stempora | |
| StepFWD | Bucharest |
| Stimasoft | Bucharest |
| STNS Development S.R.L. | |
| Stoica | |
| StradaIT | Bucharest |
| Straightad | |
| Strongbytes | Iași |
| Studio Crave | |
| Studio78 | |
| StudioWEBER | Brașov |
| Subhi.ro | Bucharest |
| Sunshine The Agency | |
| Superbet Interactive (Romania) Ltd | |