| Cyrex Enterprise | |
| D&C Software, Lda | Porto |
| Dados.gov.pt | Lisbon |
| Damascode | |
| DareData Engineering | Lisbon |
| DATABOX - Informática, S.A. | Lisbon |
| Datafields | Porto |
| DataFita Consultores, Lda | Lisbon |
| DataGate | Lisbon |
| DataLab | Lisbon |
| DataSmart | Lisbon |
| Datatekin | Lisbon |
| Decision Eyes | Lisbon |
| Delta Coders | Lisbon |
| Desassossego Studio | |
| Design Dossier | |
| DesignCorner | |
| Deskbee, Ltda | |
| Desware | Oeste |
| Dev2Grow | Lisbon |
| Didimo, S.A. | Porto |
| Digidelta-Software | Região de Leiria |
| Diginfor | Lisbon |
| Digital Health Portugal | Porto |
| Digital Spiders | |
| Digital Valley | |
| Digital24.pt | |
| Digitalis Informática | Lisbon |
| Digitalmente, S.A. | Região de Aveiro |
| DigitalSign - Certificadora Digital, S.A. | Lisbon |
| DigitalWorks | Lisbon |
| Digiwest | Região de Leiria |
| Directual | Lisbon |
| DireTube | Lisbon |
| Distinct Agency | |
| Djangoheads | |
| Dobsware | Madeira |
| doDOC Corporation | Região de Coimbra |
| DogmaSIS | |
| Doinn, S.A. | |
| Doisbr | Alentejo Central |
| Dominios.pt | Algarve |
| DOTSENKO & CO | |
| Double Design & Development | |
| Draxed | Lisbon |
| Drible | |
| Drivit | Lisbon |
| Dynasys | Lisbon |
| e-GDS | Porto |
| E-goi | Porto |