| WebLX | Lisbon |
| Weboost | |
| WebSummit | Lisbon |
| WebTuga | Cávado |
| Webuild | Lisbon |
| Webwise | Lisbon |
| webXpace | Região de Leiria |
| WeDo Technologies | Lisbon |
| WeDoTech | Porto |
| Weezie | Porto |
| Wegho | Porto |
| WeTek Soluções Tecnológicas, S.A. | Porto |
| WhiteKube | Lisbon |
| Wide Scope | Lisbon |
| Widetail, Lda | Porto |
| WidgiLabs | |
| Willbe Collective | Cávado |
| Wincode, S.A. | Porto |
| WindByInternet | Oeste |
| Winstep Software Technologies | Lisbon |
| Wire IT | |
| WIT Software, S.A. | Região de Coimbra |
| Wizardsardine, Lda | Azores |
| WLPartners | Lisbon |
| Wolf Smart Industries | |
| Womni | Lezíria do Tejo |
| Workhub | Lisbon |
| Worten | Lisbon |
| Worten - Equipamentos para o Lar, S.A. | |
| X-IMO | |
| Xecompex Equipamentos e Serviços, S.A. | Lisbon |
| Xhockware | Porto |
| xMoney | Cávado |
| Xpand IT | Lisbon |
| Xperienz | |
| Xplor - Business Solutions, SGPS, S.A. | Porto |
| Xservers | Viseu Dão Lafões |
| YD Ynvisible, S.A. | Lisbon |
| YD-Pharmaceuticals | |
| YDigital Media S.A. | Lisbon |
| YDigital Media, S.A. | Lisbon |
| Year2k | Lisbon |
| Yomoc | |
| Yomp | |
| YouBeep | |
| Youverse | Lisbon |
| Zaask - Plataforma Digital, S.A. | Lisbon |
| Zalox | Porto |
| Zarph, S.A. | Lisbon |
| Zeben Sistemas Electrónicos | Cávado |