| Mokadom S.r.l. | Milan |
| Mokap | |
| Mole Urbana | |
| Molteni Farmaceutici | |
| MOMA S.p.A. | Salerno |
| MON5 S.r.l. | |
| MondoServer IT | Lecce |
| Mondoweb S.r.l. | Rome |
| Money360.it S.p.A. | |
| Monk Software | |
| Mono S.r.l. | |
| Montebelluna Linux Users Group | Treviso |
| Monteresearch S.r.l. | |
| Moonstone Venture Capital | |
| Mopso | Milan |
| Mosft.it | Novara |
| Mostrum S.r.l. | |
| Motion Engineering S.r.l. | Biella |
| Motocicli Italiani S.r.l. | |
| Motor Valley Accelerator | Modena |
| MotorK | Milan |
| Mottura S.p.A. | Turin |
| MotusQuo S.r.l. | |
| MOVEANDCALL S.r.l. | Rome |
| Movendo Technology S.r.l. | |
| Moviement S.r.l. | Padua |
| Movinfo S.r.l. | Monza and Brianza |
| Moxoff S.p.A. | |
| Moze S.r.l. | Milan |
| MPE S.r.l. | Varese |
| MRS Solutions S.a.s. | Naples |
| MSB Software | Ravenna |
| MT Distribuzione S.r.l. | Verona |
| MTN Company S.r.l. | Salerno |
| Muffin S.r.l. | |
| Mugo S.r.l. | |
| Multi Advanced Project | Rome |
| MultiData S.r.l. | Modena |
| Multimedia S.r.l.s. | Bari |
| MultiMedia Soft | Turin |
| Multimedia Web Services | Cagliari |
| MultiMediaVda | Aosta Valley |
| MULTIWAYS//E-Strategies | Friuli-Venezia Giulia |
| MultiWire S.r.l. | Cuneo |
| Muscope Cybersecurity S.r.l. | |
| Musixmatch | |
| Mweb solution | Milan |
| My cool button | Padua |
| My Store | Rome |
| My-Money | Padua |