| Drop S.r.l. | Fermo |
| Drupal Italia | Rome |
| DS Pallas S.n.c. | Milan |
| DS4 S.r.l. | |
| DSC Group S.r.l. | |
| DSE S.r.l. | Turin |
| DSI Design S.r.l. | |
| DSM S.p.A. | Parma |
| DSP-Quattro | Rome |
| Dstech S.r.l. | Rome |
| DTS Consulting S.r.l. | |
| DuckMa S.r.l. | |
| Dune Sistemi | Rome |
| Dunp S.c.p.l. | |
| dverso Studio S.r.l. | |
| DW DreamyourMind S.r.l. | Rome |
| DW Informatica S.p.A. | Verona |
| DWS Systems | Vicenza |
| Dygroup | Turin |
| Dylog Italia S.p.A. | Turin |
| e way Enterprise Business Solutions S.r.l. | |
| E-Deare IT S.r.l.s. | |
| e-GEOS | |
| E-Lane IT Solutions | Genoa |
| E-leva S.r.l. | Pesaro and Urbino |
| E-mod | Rome |
| e-Novia | |
| E-One Group | Reggio Emilia |
| E-Plato S.r.l. | |
| e-Service di Puzzo Davide | Ragusa |
| E-side S.r.l. | Vicenza |
| E26 | Naples |
| E42 S.r.l. | Venice |
| E4A S.r.l. | Vicenza |
| EasyPol | Rome |
| EASYRAIN i.S.p.A. | |
| Easyrain i.Sp.a. | |
| Easys | Modena |
| Eataly S.p.A. | |
| Eathic S.r.l. | |
| EatsReady | Milan |
| Eave-Tech S.r.l. | |
| eBI Solutions S.r.l. | Naples |
| Echoes S.r.l. | |
| Eco4Cloud | Cosenza |
| Ecoh Media S.r.l. | Varese |
| Ecomate S.r.l. | Milan |
| Ecomatica S.r.l. | Padua |
| eCommX | |
| Econnet S.r.l. | Bologna |