| Dawan | Loire-Atlantique |
| Dawex Systems | |
| Daxium Software | Paris |
| Day One Entrepreneurs & Partners | |
| db-ip.com | |
| DBM Technologies | Métropole de Lyon |
| Dbmedia | Pyrénées-Orientales |
| DBSA | Essonne |
| DBV Technologies | |
| DBV Technologies S.A. | |
| DCbrain | |
| DCFI | Vaucluse |
| Dclic06 | Alpes-Maritimes |
| DDS Logistics | Hauts-de-Seine |
| de la Lune à la Lumière | Seine-et-Marne |
| De Medicis | |
| Deal.fr | Gironde |
| Dealing-Room | Val-de-Marne |
| Dealt | |
| Deblock S.A.S. | |
| Debugbar | Haute-Garonne |
| Decade | Paris |
| Decalog | |
| Decanet | |
| Decasoft | Paris |
| Decelect | Aisne |
| Décibel Informatique | Bas-Rhin |
| Decideo | |
| DecideOm | |
| DECISION - Études & Conseil | |
| Déclic France Informatique | Gard |
| Déclic-e média | Vienne |
| Déclic-informatique | Hérault |
| Declic-media | Haute-Vienne |
| Declicweb | Paris |
| DeDAeLe Multimédia | Gard |
| Dedalus France | Drôme |
| Dedi Agency | |
| Dedienne Aerospace | |
| Deemea S.A.S. | |
| Deep Silver | Seine-Saint-Denis |
| Deepki | Paris |
| Deeplink Medical | |
| Deepomatic S.A.S. | |
| DeepOR | Paris |
| DeepTalk | |
| Déessi | |
| Defacto | |
| Défense Datacenter | Hauts-de-Seine |
| Defensive Lab Agency S.A.S. | Paris |