| Chilkat Software | Illinois |
| Chime | |
| Chimera Bioengineering | California |
| Chimera Therapeutics, LLC | |
| Chimerix, Inc. | North Carolina |
| Chimerna Therapeutics, Inc. | |
| Chimeron Bio | Pennsylvania |
| China Aerospace Science and Technology Corporation | |
| China Great Wall Industry Corporation | |
| China Telecom Americas, Inc. | Virginia |
| China Unicom Americas Operations Ltd | Virginia |
| Chinese American Semiconductor Professional Association | California |
| Chingona Ventures | Illinois |
| Chino Computer Repair Service | California |
| Chip Diagnostics, Inc. | Pennsylvania |
| ChipAgents | |
| ChipDocs | Washington |
| ChiperOS Ltd | |
| ChipEstimate.com | California |
| Chipheads Computer Repair | Minnesota |
| Chipiron | |
| Chipletz, Inc. | |
| ChipLogic, Inc. | New York |
| Chipola College | Florida |
| Chippewa Valley Technical College | Wisconsin |
| CHIPS Technology Circuits | New Jersey |
| ChipSeeker | Massachusetts |
| Chipsy.io | |
| Chiral Photonics, Inc. | New Jersey |
| Chiral Software | California |
| ChiRhoClin, Inc. | Maryland |
| Chiron Health | |
| Chiron Software, Inc. | Texas |
| ChiroTouch | California |
| Chirp Technologies | |
| Chisel Labs, Inc. | |
| Chistadata, Inc. | Texas |
| Chittam | |
| Chkk | California |
| Chloe Capital | New York |
| Chmiel Studio | Rhode Island |
| Chmura Economics & Analytics | Virginia |
| CHO Plus, Inc. | California |
| Chocolate Software, LLC | Colorado |
| Chocolatey Software, Inc. | Kansas |
| Choice Communications | Pennsylvania |
| Choice Creative Solutions | |
| ChoiceNetworks | California |
| ChoicePrinters.com | Florida |
| Choices Software, Inc. | Massachusetts |