| Chair 10 Marketing, Inc. | Washington |
| Chair 9 Marketing | |
| Chairlift | Illinois |
| Chairseven Creative, LLC | |
| Chakery | Texas |
| Chalk Digital, Inc. | |
| Chalkbox Creative, LLC | |
| Challenger Communications | |
| Chamber Data Systems, Inc. | Texas |
| Chamber of Digital Commerce | District of Columbia |
| Chamberlain University | Illinois |
| Chameleon Consulting Group, LLC | |
| Chameleon Graphix | Ohio |
| Chameleon Headsets | California |
| Chameleon Intelligent Tech, Inc. | California |
| Chameleon IT | Massachusetts |
| Chamette Computer User's Group | Louisiana |
| Champ | Massachusetts |
| Champ Software | Minnesota |
| Champ Systems, Inc. | California |
| Champaign-Urbana Computer Users Group | Illinois |
| ChampCohen Design Associates | California |
| Champion | |
| Champion Online Marketing | |
| Champions Oncology, Inc. | New Jersey |
| Champlain College | Vermont |
| Champlain College Computer Networking & Cybersecurity Degree | Vermont |
| Champlain College Computer Science & Innovation Degree | Vermont |
| Champlain College Digital Forensics Degree | Vermont |
| Champlain College Division of Information Technology & Sciences | Vermont |
| CHAMPS Software | Florida |
| Chan Soon-Shiong Institute of Molecular Medicine at Windber | Pennsylvania |
| Chanalytic | |
| Chandra Technologies | Wisconsin |
| Chaney Systems | Wisconsin |
| Chang Bioscience, Inc. | |
| Change Healthcare | Tennessee |
| Change Machine | New York |
| ChangeEngine | |
| Changeforce.ai | New York |
| ChangeIP | California |
| Changelog | Texas |
| Changescape Web | Missouri |
| ChangeSync | Arizona |
| ChangeTower, LLC | |
| Chanimal, Inc. | Texas |
| Channakya Software | Colorado |
| Channavix Therapeutics, LLC | |
| Channel Islands PC Users Group | California |
| Channel Medsystems, Inc. | California |