| Usable Interface | New Hampshire |
| Usable Web | Ohio |
| UsableNet | New York |
| USAccess, LLC | Virginia |
| USADATA, Inc. | New York |
| Usage AI | New York |
| USAT, LLC | North Carolina |
| USAva, Inc. | |
| USB Implementers Forum, Inc. | Oregon |
| USB Stuff | California |
| USB-Port.com | New York |
| USB-Shop.com | California |
| USBFireWire | Kansas |
| USBPhoneWorld.com | Arizona |
| USC | New Jersey |
| USC Annenberg Innovation Lab | California |
| USC Institute for Creative Technologies | California |
| USComponent.com | Oklahoma |
| Uscreen | |
| USCWS | Pennsylvania |
| Use All Five, Inc. | California |
| UseAgility | Missouri |
| UsedHandhelds.com, Inc. | Iowa |
| UsedMac, Inc. | California |
| Usedmacs.us | California |
| UsedRouter.com | Missouri |
| Usedtowers | Arkansas |
| Useful Software, Inc. | Georgia |
| Useful Studios | Virginia |
| USENIX Association | California |
| User Evaluation | |
| User Friendly Technology Services | |
| User Solutions, Inc. | Michigan |
| User X, LLC | |
| User-Friendly Computing | California |
| User10, LLC | Arizona |
| USEReady | New York |
| UserEasy.com | Michigan |
| UserEcho, LLC | Illinois |
| UseResponse, Inc. | Delaware |
| UserEvidence | |
| Userflow, Inc. | |
| Userfront | |
| Userlist, Inc. | Georgia |
| Userlytics Corporation | |
| uSERP | Colorado |
| Userpilot | Texas |
| UserSoft Technology | Texas |
| UserTesting | California |
| UserVoice | California |