| SproutLoud Media Networks, LLC | Florida |
| Sproutvideo | New York |
| Sproutward | Massachusetts |
| Sprowtt | Florida |
| Spruce | New York |
| Spruce Biosciences, Inc. | California |
| Spruce Infotech, Inc. | Pennsylvania |
| Spruce Labs, Inc. | |
| Spruce Power | |
| Spruce Technical Systems, Inc. | New Jersey |
| SpruceID | New York |
| Spry | Washington |
| Spry Digital | Missouri |
| SPRY Therapeutics, Inc. | |
| Spryte Medical, LLC | |
| SPRYY | |
| SPS Commerce, Inc. | Minnesota |
| SPS Group, Inc. | |
| SPsoft | |
| Spud Software | Michigan |
| Spud Software | |
| Spur | New York |
| Sputnik Investments | Texas |
| Spy Dialer Labs, Inc. | |
| Spy Dialer, Inc. | |
| SpyCloud, Inc. | Texas |
| Spyder Byte Media, Inc. | Michigan |
| Spyderbat, Inc. | |
| SpyderWise Media | Utah |
| Spydex, Inc. | Delaware |
| SpyFu, Inc. | Arizona |
| SpyGlass Pharma, Inc. | |
| Spyre Therapeutics, Inc. | |
| Spytec GPS | New York |
| Spytech Software and Design, Inc. | Minnesota |
| Spyware Terminator | Florida |
| SQ2 Media, LLC | |
| SQA Advisory | Florida |
| SQA Solution, Inc. | California |
| Sqaure63 | Texas |
| SQDM | Texas |
| Sql Backup and FTP | New Jersey |
| SQL Maestro Group | New York |
| Sql Power Tools, Inc. | Wyoming |
| SQL Sentry, Inc. | North Carolina |
| SQL Studio | Michigan |
| SQLCare, Inc. | California |
| SQLData Systems, Inc. | Virginia |
| SqlDBM | |
| SqlDbx | New York |