| Mediadisseny.com | Barcelona |
| Mediaelx | Alicante |
| Medibiofarma, S.L. | |
| Medicsen | Madrid |
| Mediktor | Barcelona |
| Medios y Redes Online, S.L. | Madrid |
| MediQuo | Barcelona |
| MediterráneaJS | Barcelona |
| Mediterranean Consulting | |
| Mediterrani University School Barcelona | |
| MedLumics, S.L. | Madrid |
| MedUX | Madrid |
| Meep.app | Madrid |
| Megastar, S.L. | Barcelona |
| Megatró Grup | Girona |
| MeiT | |
| Mensoft | Madrid |
| Mensoft Consultores, S.L. | Madrid |
| MENTAData Sistemas de Información, S.L. | Madrid |
| Mentioned | Barcelona |
| Mercantil de Informática, S.A. | Madrid |
| Meridiem Games | Madrid |
| Merkatu Interactiva, S.L. | |
| Merlin Cantabria | Cantabria |
| Mesala SICI, S.L. | Valencia |
| MESbook | Valencia |
| Mestrelab Research, S.L. | A Coruña |
| Metacampus, S.L. | Barcelona |
| Metaestudio | Barcelona |
| Metafase | Madrid |
| Metafrase Seguridad Informática | Madrid |
| Metasport Arena, S.L. | Barcelona |
| Metaverse News | Barcelona |
| Metaverso360.io | Sevilla |
| Metech | Madrid |
| Methinks | Barcelona |
| Metriplica | Barcelona |
| Metxa Aceleradora de Proyectos, S.L. | Álava |
| Meytel | Madrid |
| MG Comunicación, S.L. | Madrid |
| Micappital | Madrid |
| Mick Graham Computers | Valencia |
| Microarea, Inc. | Valencia |
| Microasis, S.L. | Biscay |
| MicroBR Comunicaciones, S.A. | Barcelona |
| MicroCAD | Málaga |
| Microcom Sistemas Modulares, S.L. | Gipuzkoa |
| Microfusa, S.L. | Barcelona |
| Microgal, S.L. | Pontevedra |
| Microjogos.com | Barcelona |