| Relikon | South Bačka |
| Reload Agency | |
| Remote Human | Belgrade |
| Reputeo | |
| RIA Software | Pomoravlje |
| Romsym Data d.o.o. | Belgrade |
| RoundCube | |
| Royalimpex | Mačva |
| RT-RK Institute for Computer Based Systems | South Bačka |
| Runa Media | South Bačka |
| RUR | Belgrade |
| S7 Code&Design | |
| S8 Studio | Belgrade |
| Safeberry | |
| Saga d.o.o. | Belgrade |
| Sally Engineering | |
| SBB | Belgrade |
| SBB d.o.o. | Belgrade |
| Scuti IT | |
| SEE ICT | Belgrade |
| Semaphore Technologies d.o.o. | South Bačka |
| SEO Blog optimizacija sajta | Belgrade |
| SEO Optimizacija | Belgrade |
| Serbia Start Up | Belgrade |
| Serbian Academy of Sciences and Arts - Mathematical Institute | Belgrade |
| Serbian Games Association | Belgrade |
| Serbian Private Equity Association | Belgrade |
| Serbian.tech | Moravica |
| Servis mobilnih telefona Doktor Mobil | Belgrade |
| Servis Monitor Nis | Nišava |
| Servis Računara Reality | Belgrade |
| Seven Serbian Venture Network | Belgrade |
| Signal Komunikacije | Belgrade |
| Simple Solutions | |
| Singi | Belgrade |
| Sipod | |
| SITO | Belgrade |
| Sixpack dizajn studio | Belgrade |
| SkyHosting | Belgrade |
| SMART | South Bačka |
| Smart Technologies LLC d.o.o. | |
| SmartCat | South Bačka |
| SmartNet | Nišava |
| SMDesign | Nišava |
| SmileSoft S.A. | Pomoravlje |
| Softek | Zlatibor |
| SoftKom | Belgrade |
| SoftSerbia IT Outsourcing | Belgrade |
| Solfins d.o.o. | Belgrade |
| Sotex Solutions | |