| Quinsam Communications Group | British Columbia |
| Quinte Computer Services Ltd | Ontario |
| Quintel Communications Ltd | |
| Quintessential Computing Services, Inc. | Alberta |
| Quinzee | |
| Quist Consulting | Ontario |
| Qulliq Energy Corporation | |
| Quoded | |
| Quokka Systems | British Columbia |
| Quoly.com | Quebec |
| Quorum | |
| Quorum Corporation | Alberta |
| Quorum DMS | |
| QuoteMachine | |
| Quoter Software, Inc. | British Columbia |
| Quoter XR | Quebec |
| Quovim C3 | Quebec |
| QurCan Therapeutics | |
| Quresoft | |
| Qvella Corporation | |
| QWebsites | Ontario |
| Qwerty Computers & Communication Cabling, Inc. | Alberta |
| Qwick Media, Inc. | |
| QxMD | |
| R & D Business Systems Ltd | British Columbia |
| R & D Systems Auditing, Inc. | |
| R Technologies | |
| R U On The Net, Inc. | British Columbia |
| R&D Capital | |
| R&D Computer Solutions | Ontario |
| R&D Partners | |
| R&G Strategic Communications | |
| R&T Network Solutions | |
| R-Comp | Ontario |
| R-LABS Canada, Inc. | |
| R-Tools Technology, Inc. | Ontario |
| R. W. Stewart | Ontario |
| R. White Woods, Inc. | British Columbia |
| R.A.L.E. Respository | Manitoba |
| R.G. Potter Consulting Services, Inc. | Ontario |
| R.M.T.P. Co. | Ontario |
| R.P. Electronic Components Ltd | British Columbia |
| R.S. Digital Solutions | Alberta |
| r42 communication, Inc. | Quebec |
| R4Systems, Inc. | Ontario |
| Rablab | Quebec |
| Raccoopack Media | |
| Race Data | |
| RaceRocks 3D | |
| Rack911 Labs | |