| Ironclad TEK | |
| Irondevs | |
| IRONFIN | Ontario |
| Ironflow Technologies, Inc. | New Brunswick |
| IronGate Server Management & Consulting | Ontario |
| IronOak Games, Inc. | |
| IronOak IT | Alberta |
| Ironstone Technologies, Inc. | Manitoba |
| Irosoft | Quebec |
| Irotronics, Inc. | Ontario |
| Irwin | Ontario |
| IS2 Workforce Solutions | |
| iS5 Communications, Inc. | Ontario |
| Isaacs IT Consulting | Manitoba |
| Isaacs Software | Ontario |
| IsaiX Technologies, Inc. | Quebec |
| ISARA Corporation | Ontario |
| Isarta | Quebec |
| ISCAPE Internet Consulting | British Columbia |
| ISCI, Inc. | Quebec |
| Iseehear, Inc. | Ontario |
| Isekit Technologies, Inc. | |
| iService | Ontario |
| isgSearch | |
| iSi LIVE | Ontario |
| Isigma Solutions | Ontario |
| iSIGN Media Corporation | Ontario |
| ISIS Secur, Inc. | Quebec |
| iSkin | Ontario |
| ISL Communication | Quebec |
| Island | |
| Island Capital | |
| Island Coyotte Tech, Inc. | |
| Island Foxtail Technology | |
| Island IT | British Columbia |
| Island Key Computer Ltd | British Columbia |
| Island Microsystems Ltd | British Columbia |
| Island Savings | |
| Island Technologies Computer Systems | British Columbia |
| IslandIT | Newfoundland and Labrador |
| Islandnet.com | British Columbia |
| Islandora Foundation | |
| IslandWater Technologies | Prince Edward Island |
| ISM Arts & Culture | |
| ISM Canada | Saskatchewan |
| ISMA Microsolutions | Quebec |
| Ismoip Digital | Ontario |
| ISN Technologies | Ontario |
| Isoft, Inc. | Ontario |
| Isologic Radiopharma | |