| Drafting Clinic Canada Ltd | Ontario |
| Draganfly, Inc. | |
| Draganfly Innovations, Inc. | Saskatchewan |
| Draggon Informatique | Quebec |
| DragonFire, Inc. | |
| Dragonfly Designs | Ontario |
| Dragonfly Information Technology, Inc. | Ontario |
| DragonWave-X | Ontario |
| Drake Media, Inc. | |
| Drakkar | Quebec |
| Drapper Labs | British Columbia |
| Drastic Technologies Ltd | Ontario |
| Dre Designs, Inc. | British Columbia |
| Dream in Design | British Columbia |
| Dream Maker Ventures | |
| Dream Payments Corporation | Ontario |
| Dream Photonics, Inc. | |
| Dream Studio 9, Inc. | Ontario |
| Dreamscape | |
| Dreamz Consulting, Inc. | Ontario |
| Dreamz Infosys | Ontario |
| Dreeven Technologies, Inc. | Quebec |
| Dreiden, Inc. | Ontario |
| DrillDraw | Quebec |
| DRIP Marketing | |
| Drishya.ai | |
| DriveSync | Ontario |
| DriveTraffic | Ontario |
| Drivewyse, Inc. | Alberta |
| DRK Informatique | Quebec |
| Droctech | Nova Scotia |
| Drone Vision International | Quebec |
| DroneTechnic | |
| DroneXperts | Quebec |
| Drop Fake, Inc. | |
| Drop Technologies, Inc. | |
| Drop That Code | |
| Dropkick Studio | |
| Dropping.ca | Ontario |
| Druide informatique, Inc. | Quebec |
| Drummond économique | |
| Drupal Web Development | British Columbia |
| Drupfan Software | |
| DRVGEN, Inc. | |
| DRWN | |
| Dryden Municipal Telephone System | Ontario |
| DS Digital Media | |
| DS01 | |
| DSA Ocean | British Columbia |
| DSAHR, Inc. | Quebec |